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Simply put,   Tylosin   is a natural antibiotic made from bacteria. It works by interfering with the ability of other bacteria to make proteins. It only affects the manufacture of bacterial proteins and therefore does not affect the protein manufacture of mammals, birds or reptiles. Tylosin is a macrolide antibiotic (the same as erythromycin).   How to use this drug? Tylosin is licensed for use in livestock as a broad-spectrum antibiotic for the treatment of infections, but it has other uses that are not related to its antibiotic activity. In small animals, the antibiotic properties of tylosin are barely used compared to its anti-inflammatory properties in the intestine. Its main use in pets is to treat colitis. In this case, it is not used as an antibiotic to treat the infection, but as an anti-inflammatory to soothe the colon.    Although there are few formal studies examining this non-antibacterial property of tylosin, it does appear to be effective in this regard and there are many

  ZUPREVO is a clear yellowish ready-to-use sterile injectable solution containing   tildipirosin , a semi-synthetic macrolide antibiotic. Each mL of ZUPREVO contains: ACTIVE INGREDIENT: 180.0 mg of tildipirosin as the free base; NON-MEDICINAL INGREDIENTS: citric acid monohydrate, propylene glycol, and water qs.   Zuprevo Indications ZUPREVO is indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni. ZUPREVO is also indicated for the reduction of morbidity associated with BRD in feedlot calves, caused by Mannheimia haemolytica, Pasteurella multocida and Histophilus somni, during the first 14 days in the feedlot, when administered at the time of arrival.   Dosage and Administration ZUPREVO should be administered in the neck of cattle by a single subcutaneous injection at a dose rate of 4 mg/kg body weight (1 mL/45 kg). Do not inject more than 10 mL into a single site. Do not puncture the stopper